Toxicological approaches to complex mixtures.

Toxicological approaches to complex mixtures.

This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemio...

Statistical approaches to toxicological data.

Statistical techniques as applied to toxicological data are discussed. Issues concerning statistical hypothesis testing and combining studies are considered as well as design of experiments. The problems surrounding risk assessment are also mentioned.

Toxicological evaluation of complex mixtures by pattern recognition: correlating chemical fingerprints to mutagenicity.

We describe the use of pattern recognition and multivariate regression in the assessment of complex mixtures by correlating chemical fingerprints to the mutagenicity of the mixtures. Mixtures were 20 organic extracts of exhaust particles, each containing 102-170 individual compounds such as polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs, oxy-PAHs, and saturated hydrocarbons. Mixtures were ...

The Liquid Density of Complex Liquid Mixtures

A second virial coefficient correlation suitable for two different temperatures ranges, (T*)-2£180 and (T*)-2>180, where T* is RT/DHvap is presented. The equation of state can be calculated for different, complicated non-polar, and slightly polar liquid mixtures at any temperature over the range from Ttp to T<su...

Mixtures of Metals and Polynuclear Aromatic Hydrocarbons May Elicit Complex, Nonadditive Toxicological Interactions